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Regeneron’s Eylea combo therapy fails study

Regeneron Pharmaceuticals’ combo therapy containing its flagship eye drug, Eylea, was inferior to Eylea alone in a mid-stage trial involving patients with wet AMD.

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Trial Failure Forces Bay Area’s Threshold Pharma to Cut Almost a Quarter of Workforce

Shares of Threshold Pharmaceuticals plunged more than 58 percent in pre-market trading after the company announced it was terminating about one-fourth of its workforce following the failure of its Phase II cancer treatment.

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Alnylam Falls After Stopping Development of RNAi Liver Disease Candidate ALN-AAT

Alnylam Pharmaceuticals recently presented 10 posters and oral presentations showing the progress of its GalNAc platform and its clinical translation at the 12th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS) in Montreal. Included in the presentations was a bit of a bomb – in its Phase I/II study of ALN-AAT to treat AAT deficiency-associated liver disease (alpha-1 liver disease), three patients showed asymptomatic, transient increased liver enzymes. As a result, it has halted.

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Struggling ImmunoGen Eliminates 17% of Workforce After Strategic Review

After a strategic review of its operations and pipeline, Waltham, Massachusetts-based ImmunoGen announced that it will cut 17 percent of its staff, or 65 jobs.

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Deaths Lead Boehringer to Cancel Deal With Hanmi

Just a day after Hanmi Pharmaceutical announced a deal with Genentech, Boehringer Ingelheim terminated a license deal because of patient deaths.

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Alcobra plunges after FDA places hold on ADHD drug

Alcobra Ltd.’s market value more than halved a day after the company said the U.S. Food and Drug Administration had placed a hold on its lead experimental drug.

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Study finds Zika infects neural cells related to skull formation

The Zika virus can infect and alter cells in the human nervous system that are crucial for formation of bones and cartilage in the skull, a study found.

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Horizon Pharma to pay Express Scripts $65 million to settle rebate litigation

Horizon Pharma said it would pay pharmacy benefit manager Express Scripts Holding $65 million to settle litigation related to after-market rebates for three of its medicines.

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Amgen, Arrowhead team up on gene-therapies for heart disease

Amgen Inc. said it would buy a stake in Arrowhead Pharmaceuticals Inc. and collaborate with the company to develop gene-silencing therapies for heart disease.

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