The three largest U.S. drug distributors and drugmaker Johnson & Johnson agreed to pay $590 million to resolve claims by Native American tribes that the companies fueled an opioid epidemic in their communities, according to court filings.

Oxycontin

A federal judge on Feb. 1 extended a legal shield protecting the Sackler family owners of Purdue Pharma from lawsuits to Feb. 17, as they try to reach a deal with several states to settle sprawling litigation stemming from the U.S. opioid crisis.

Leading South African scientists are set to investigate COVID-19 and HIV in tandem, amid mounting evidence that the collision of the two pandemics could be generating new coronavirus variants.

Oxycontin

Members of the Sackler family who own Purdue Pharma LP are nearing an agreement to boost their more than $4 billion offer to resolve sprawling opioid litigation after negotiating with states that had objected to terms of the OxyContin maker’s bankruptcy reorganization, according to a court filing.

The prevailing theory about the Omicron variant is that it is going to rip through the population quickly and possibly burn out, marking the downside of the COVID-19 pandemic. But researchers are expressing concern about a subvariant of Omicron dubbed BA.2 that appears to be tearing through Denmark, just as the first Omicron wave subsided.

U.S. cities and counties have embraced a proposed settlement worth up to $26 billion resolving lawsuits alleging three large drug distributors and drugmaker Johnson & Johnson fueled the U.S. opioid epidemic, lawyers behind the deal said on January 26, increasing the odds that it will move forward.

BlueWillow Biologics demonstrated the safety and immunogenicity in humans of the company’s intranasal technology, which CEO Chad Costley said is the only adjuvanted intranasal platform that is not virus-based.

Building on Novo Nordisk’s success during June 2021 in obtaining the first drug approval for weight management since 2014, the Danish pharma giant is partnering with biotech company EraCal Therapeutics to develop new obesity-related drug targets. 

Merck’s HIV strategy took a major hit as a “very important” aspect, MK-8507, was paused in development after patients experienced a low white blood cell count. East coast neighbor Enanta is also feeling the sting of a failed program with HBV trials, as the Massachusetts biotech is dropping the oral hepatitis B virus RNA destabilizer EDP-721 after healthy participants experienced safety signals.

A new study shows the persistent syndrome of Covid-19 after-effects known as long Covid can develop after “breakthrough” infections in vaccinated people. Other new findings suggest a gene that helps the coronavirus reproduce itself might contribute to life-threatening Covid-19 in young, otherwise healthy people.