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Shire’s Hunter Syndrome Treatment Fails Study Goals

Shire’s experimental treatment SHP609 to address cognitive impairment in pediatric patients diagnosed with the rare disease known as Hunter syndrome failed a key trial.

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Allergan, Richter’s bipolar depression drug succeeds in key trial

Allergan and Gedeon Richter’s drug cariprazine to treat severe bipolar depression in adults met the main goal of a late-stage study.

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Keytruda Fails Phase III Stomach Cancer Study

Merck & Co.’s Keytruda came up short in a pivotal study as a second-line treatment for patients with advanced gastric or gastroesophageal junction adenocarcinoma.

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Bumper crop of new drugs fails to lift big pharma R&D returns

2017 has shaped up to be a bumper year for drug approvals, with U.S. officials clearing twice as many novel medicines as in 2016, yet returns on research investment at leading pharmaceutical companies are down.

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Genentech’s Hemlibra Data Wows at ASH

At the American Society of Hematology meeting, Genentech revealed long-term data showing the drug maintains its efficacy over an extended period of time.

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Verastem Announces Pivotal Clinical Data

The DUO study showed statistically significant PFS improvement for duvelisib versus standard of care treatment ofatumumab.

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Lilly’s Cyramza meets main goal for gastric cancer

Eli Lilly & Co.’s Cyramza met the main study goal but failed to improve survival rates in a late-stage trial for gastric cancer.

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Breast cancer drug superior to chemo in study

Pfizer’s talazoparib for advanced breast cancer was demonstrated to be superior to chemotherapy in a late-stage study.

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Roche study: Cancer ‘Velcro’ halts T-cell attack

Roche scientists may have discovered why some tumors resist new immunotherapy drugs as well as a possible means of turning the tables to incite a T-cell attack.

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Sage’s depression drug succeeds in study

Sage Therapeutics Inc.’s drug to treat patients with moderate to severe depression met the main goal in a mid-stage study.

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Sanofi’s Toujeo met main objective in study

Sanofi’s Toujeo met the primary study objective in the first large head-to-head clinical trial, called BRIGHT study, comparing Toujeo with insulin degludec.

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Sanofi ends development of C. difficile vaccine

Sanofi SA ended development of an experimental vaccine for Clostridium difficile infection.

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Bristol-Myers’ Lung Cancer Opdivo Trial Stopped Early for Superior Overall Survival

Bristol-Myers Squibb announced that the company’s Phase III trial pitting Opdivo against chemotherapy drug docetaxel in treating certain lung cancer patients was stopped early after meeting key endpoints.

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Aimovig Halves Length of Migraine Attacks in Study

Amgen unveiled results from a late-stage study that shows the company’s Phase III drug Aimovig reduced monthly migraine attacks in half.

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Merck KGaA, Pfizer’s immunotherapy fails in gastric cancer trial

Germany’s Merck KGaA suffered a setback in the development of the company’s key cancer immunotherapy Bavencio, which failed in a trial to prolong lives in gastric cancer patients when compared with standard chemotherapy.

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Ardelyx to Ditch Phase III Hyperkalemia Drug

Ardelyx decided to shutter development of RDX7675 – an experimental medicine for hyperkalemia – including the onset-of-action trial and Phase III studies.

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Cytokinetics abandons ALS drug after failed trial, shares tank

Cytokinetics Inc. will stop developing one of its treatments for ALS – which afflicts Stephen Hawking – after the drug failed in a late-stage trial, sending the company’s shares tumbling about 35 percent.

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Roche stock up $12 billion on cancer, hemophilia trials

Roche shares were lifted by two clinical trial wins for its new cancer and hemophilia drugs, potential blockbusters that the Swiss drugmaker is counting on to offset shrinking revenue from older medicines.

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Argos Reports Positive Kidney Cancer Data

Argos Therapeutics announced positive interim data for the company’s kidney cancer drug Rocapuldencel-T from a Phase III clinical trial.

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Nanotech, gene editing used to edit cholesterol gene: U.S. study

U.S. researchers have used nanotechnology plus the powerful CRISPR-Cas9 gene editing tool to turn off a key cholesterol-related gene in mouse liver cells.

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