Make or break: Retention tactics key	May 2009

By Michael Christel

When it comes to successfully completing clinical studies, keeping patients enrolled is crucial. With a dropout rate in Phase II/III trials still in the 20% to 30% range, adopting more effective patient retention and compliance measures remains a top priority. In most cases, experts say, the best ways to keep a participant engaged in a study are through education, communication, and appreciation.  According to Icon Clinical Research (inconclinical.com), a contract research company, important elements of a successful patient retention program include site support services; patient educational and support programs; caregiver educational and support programs; and strategic study refresher initiatives.

TAPPED IN

Mobile technologies, in particular, can play an unique role in patient retention efforts. According to Carmen Gonzalez, manager of strategy and communications at Healthcare Communications Group (hcg.com), messaging services have grown quite sophisticated in offering text, email, and phone reminders, many specializing in medical compliance. With proper IRB approval, Ms. Gonzales says there are several ways to use mobile technologies to assist with clinical trials subject retention:

SPEAKING OUT

• “Retention efforts start at the consenting stage, when the potential participant is learning why they should consider enrolling in the study.  Education on the study rationale and the potential benefit to them and/or others, lays the foundation for their commitment to the study. The better they can relate to and verbalize the objective of the study, the more likely they are to enroll and to complete the study. To varying degrees, patients also want to feel that they are partners with their study team and the larger trial effort, working together to learn more about their condition and the potential new treatment. High level information sharing, such as the number of participating sites and countries, anticipated study completion, and plans for publication of results, all support a greater sense of involvement.”
– Helen West, VP of strategic development, MMG Inc. (mmgct.com)

•“The retention program should be a cohesive program designed to make the study participant feel involved, with a sense of belonging and purpose.  An appropriate frequency of communication must be employed with appreciation items that will appeal to the participating patient population. “   
– Donna Beasley, VP of operation, Praxis (gopraxis.com)

• “To enhance retention of obese participants in long-confinement studies, we have engaged a masseuse on-site to provide back massages. We’ve even brought in a hairdresser, organized various activities such as talent shows, arranged  for pedicures, manicures, facial massages, beading and other craft activities to help participants pass the time.”
–  Sean Heyen, global director of recruitment for early stage development, MDS Pharma Services (mdsps.com)