The FDA issued a warning about a possible increased risk of hip, wrist, and spinal fractures with high doses or long-term use of proton pump inhibitors, and so product labeling will be changed. The products include Nexium, Dexilant, Prilosec, Zegerid, Prevacid, Protonix and Aciphex. Over-the-counter versions include Prilosec OTC, Zegerid OTC and Prevacid 24HR. “Epidemiology studies suggest a possible increased risk of bone fractures with the use of proton pump inhibitors for one year or longer, or at high doses,” Joyce Korvick, deputy director for safety in the FDAs Division of Gastroenterology Products, says in a statement. Most of the studies evaluated people 50 years or older, and the increased risk of fracture primarily was observed in this age group (there's more info, including a table of epidemiologicalhere).