Hello, everyone, and how are you today? A shiny day is unfolding here on the Pharmalot corporate campus, where we are scurrying to deposit the short people at their various schoolhouses. We know you can relate to the hustle-bustle. Meanwhile, we are coping by brewing another delicious cup of stimulation - our flavor today is Cinnamon Cream Swirl. We hope you will join us. Or at least pick up a bottle of water. Now, though, the time has come to start the day. So here are some tidbits. Good luck...
Interim Analysis Of Merck Vytorin Trial Is Delayed (Reuters)
Most Dementia Case Are Not Diagnosed: Study (Reuters)
Lilly And Novo Diabetes Meds Scrutinized For Cancer Tie (Bloomberg News)
Ex-Genzyme CEO Gives $10M For MassGen Cancer Unit (Boston Globe)
Pfizer Has Trouble Distributing Meds To Australian Pharmacists (Canberra Times)
Cholesterol Levels Linked To Alzheimer's (Bloomberg News)
Patheon Plans Facility Cuts As Part Of Restructuring (Outsourcing Pharma)
Teva Receives FDA Close-Out Letter Over Jerusalem Plant (Reuters)
Genentech Files For FDA Approval Of Skin Cancer Drug (Pharma Times)
Novartis Forecasts More Savings From Alcon (Bloomberg News)
Indian Government Is Not Fully Briefed On Gleevec Suit (Economic Times)
Australia Has Some Of The Most Expensive Meds (Sydney Morning-Herald)
Biologics Expects To Double Its Staff (Charlotte News-Observer)
EDITOR'S NOTE: Please check this post for updates throughout the morning
1 Comment
The dementia paper is a "no brainer" so to speak. Most patients who show pathological changes at autopsy indicating Alzheimers Disease show a vascular component as well. The only really pure form of AZ is when we see early onset AZ in patients in their 50's, and these cases are almost never missed. Most older patients have what we call a mixed dementia.
In the upcoming DSM-V there is is talk of even dropping the pure names of Alzheimers and Vascular Dementia and classifing as something like Dementia, with subcategories of Alzheimer's Type or Vascular Type.
The paper also goes against conventional thinking that low, rather than high cholesterol may be associated with AZ, since cholesterol is required for cell membrane formation in the CNS, and that a deficit of cholesterol may impede signal transmission.