Hello, everyone, and welcome to Monday. We hope the weekend was refreshing and relaxing. Now, though, that challenging routine of deadlines and meetings has returned. You know what this means - a cup of stimulation is in hand. So please join us. And here is another invitation - our webinar tomorrow on Accountable Care Organizations (details are here). Meanwhile, here are some tidbits to get you started. Hope your day goes well...
Valent To Pay $180M For Russian Specialty Pharma (Canadian Business)
Merck Bloodthinner In Limbo After Mixed Study Results (Reuters)
Roche Denies Price Cuts Tied To Bayer Case (Hindu Business Line)
Roche Extends Illumina Bid Again (Bloomberg News)
Experimental Amgen Drug Slashed Cholesterol By 66 Percent (Reuters)
Brazilian Judge Annuls Abbott Patent On Kaletra (Pharma Times)
First Trial Dates Set Against Pfizer Over Chantix (Birmingham News)
J&J Risperdal Trial To Begin In Arkansas (Associated Press)
ADHD Diagnosis Rates Rose Sharply In The Past Decade (HealthDay)
India's Flawed Treatment Allows Drug-Resistant TB To Fester (MSNBC)
Environmentalists Slam EPA Plan For Pfizer Superfund Site (Star-Ledger of NJ)
EDITOR'S NOTE: Please check this post for updates throughout the morning
2 Comments
Again, Steve Nissen doesn't know what he is talking about. Statins upregulate LDL receptor synthesis by inhibiting HMG CoA reductase, essentially starving the liver of cholesterol. PCSK9 inhibitors work by inhibiting the enzymatic pathway that reduces LDL receptor synthesis. Completely unrelated pathways, but, as usual, simplistic Steve is too involved with biochemical politics to understand biochemical pathways.
Here's the review of PCSK9 in Journal of Lipid Research:
http://www.jlr.org/content/49/6/1152.full
The new diagnostic criteria for ADHD is whether a teenager can send more than 100 tweets/hour, 200 texts/hour, and/or can drive 75 mph with his knees while tweeting with one hand and e-mailing on a smartphone with the other hand while while at the same time eating a bologna sandwich or toking some fine hashish on a bong.
Based on what I've seen of this motley crew I say we go back to the former diagnostic term- mimimal brain dysfunction, and for some of these whacked out teens it's more than minimal.