Highlights of ISMP's QuarterWatch report include: More than 1,000 reports of patient deaths were received for GlaxoSmithKline's Avandia in the first three quarters of 2009, more than any other drug the non-profit monitors. Most deaths were attributed to cardiovascular causes and ISMP says that Glaxo responded by saying "most reports were generated by lawsuits."
In the third quarter of 2009, AstraZeneca's Seroquel antipsychotic, was the suspect drug in more possible cases of diabetes than all other drugs combined. The drugmaker explained this by saying the cases were related to lawsuits.
ISMP also "observed a signal" for adverse events associated with the AndroGel and Testim sex hormone products, which are applied to the skin as a gel. Although approved only for use in men, ISMP observed 155 cases of reported injury in women and 22 events in children in the first three quarters of 2009, suggesting accidental exposure and inappropriate off-label use continues to cause injuries.