More than 100 Boston-area employees from two pharma companies are getting pink slips. Roche and Forma Therapeutics filed WARN notices with the state of Massachusetts.

ASLAN Pharmaceuticals is cutting staff and initiating a corporate restructuring and strategic prioritization of the company’s clinical development programs. Aduro Biotech will institute a “strategic reset” to focus on the company’s core strengths of the discovery and development of novel product candidates in the stimulator of interferon genes and a proliferation-inducing ligand pathways.

San Francisco-based uBiome laid off about 10 percent of the company’s staff and Dublin-based Theravance Biopharma cut 50 employees as part of a focus on the execution of strategic programs.

South San Francisco-based Five Prime Therapeutics announced the elimination of 41 jobs, or about 20 percent of the company’s headcount, as part of a restructuring program.

Pfizer is ending five preclinical programs in the biosimilar area and cutting 150 positions in Lake Forest, Illinois and in Chennai, India.

AstraZeneca filed a Worker Readjustment and Retraining Notification Act (WARN) notice with the State of Colorado, indicating plans to lay off 210 people in Boulder and Longmont.

Selecta Biosciences announced restructuring efforts that include reducing the Watertown, Mass.-based company’s workforce by 36 percent.

South San Francisco-based Genentech filed with the State of California, indicating that the Roche company planned to cut 83 jobs.

Here is a look at BioSpace’s top 10 stories of 2018.

Bayer will cut 12,000 jobs as the company prepares a business overhaul, including an exit from the animal health division.