AstraZeneca said on Monday the company will discontinue a late-stage trial for the heart disease drug Epanova to treat patients with mixed dyslipidemia and expects a $100 million writedown to hit its core profit in the fourth quarter.

AstraZeneca announced that after a recommendation from an independent Data Monitoring Committee, the company was abandoning the Phase III STRENGTH trial for Epanova (omega-3 carboxylic acids) for mixed dyslipidemia. Acasti Pharma’s Phase III TRILOGY 1 trial for the fish oil-based candidate CaPre (omega-3 phospholipid) for severe hypertriglyceridemia did not reach statistical significance.