Merck announced that the company’s proposed treatment Keytruda for non-small cell lung cancer delivered positive results from a Phase III trial.
Opdivo Significantly Improves DFS vs. Placebo as Adjuvant Therapy for Patients with High-Risk, Muscle-Invasive Urothelial Carcinoma
Blockbusters, Clinical Trials, Disease-Free Survival (DFS), Immunotherapies, Metastatic Urothelial Carcinoma (mUC), PD-1/PD-L1 inhibitors, Placebo, Primary Endpoints, R&D, Solid Tumors, Therapeutics, TumorsBristol Myers Squibb announced that CheckMate -274, a pivotal Phase 3 trial evaluating Opdivo (nivolumab) after surgery in patients with high-risk, muscle-invasive urothelial carcinoma, met primary endpoints of improving disease-free survival (DFS) versus placebo in both all randomized patients and in patients whose tumor cells express PD-L1 ≥1% (programmed death-ligand 1).
AstraZeneca’s Tagrisso Continues to Make Strides in Phase III Lung Cancer Trial
Analysis, Blockbusters, Central Nervous System, Clinical Data, Clinical Trials, Disease-Free Survival (DFS), Epidermal Growth Factor Receptor-Mutated (EGFRm) Non-Small Cell Lung Cancer (NSCLC), European Society for Medical Oncology (ESMO), R&D, TherapeuticsAstraZeneca released new results from the company’s ADAURA Phase III trial showing that Tagrisso (osimertinib) demonstrated clinically meaningful improvement in central nervous system disease-free survival in the adjuvant treatment of patients with early-stage epidermal growth factor receptor-mutated non-small cell lung cancer (NSCLC), after complete tumor resection.
AstraZeneca released detailed data from the Phase III ADAURA clinical trial of Tagrisso (osimertinib) in early-stage epidermal growth factor receptor-mutated non-small cell lung cancer
Roche company Genentech announced that the Phase III IMvigor010 trial of Tecentriq as a post-surgery monotherapy did not hit the primary endpoint in muscle-invasive urothelial cancer (MIUC).