A third dose of the COVID-19 vaccine from Pfizer (PFE.N) and BioNTech (22UAy.DE) produced significant protection against the Omicron variant of the coronavirus in healthy children ages 5 to 11, the companies said on April 14.

Global COVID-19 cases surpassed 500 million on April 14, according to a Reuters tally, as the highly contagious BA.2 sub-variant of Omicron surges in many countries in Europe and Asia.

Pfizer Chief Executive Albert Bourla said on April 13 that the company could possibly develop a new vaccine that protects against the Omicron variant as well as older forms of COVID-19 by autumn.

The BA.2 Omicron subvariant of the coronavirus is responsible for 86% of U.S. COVID-19 cases and more than 90% of infections in the Northeast, according to data on April 12 from the U.S. Centers for Disease Control and Prevention (CDC).

An experimental drug being developed by RedHill Biopharma Ltd. that improved outcomes in a randomized trial involving severely ill COVID-19 patients infected with earlier versions of the coronavirus is showing promise against the Omicron variant in test tube experiments, researchers said. Additionally, people living with well-controlled HIV infections are likely to have immune responses to the mRNA COVID-19 vaccines from Moderna and from Pfizer/BioNTech similar to those of otherwise healthy individuals, according to new data.

The World Health Organization said on April 11 it is tracking a few dozen cases of two new sub-variants of the highly transmissible Omicron strain of the coronavirus to assess whether they are more infectious or dangerous.

Current COVID-19 vaccines are not well-matched against the BA.2 sub-variant of Omicron, the U.S. Food and Drug Administration said on April 6, as its panel of outside experts meets to discuss changes to future booster doses.

A fourth dose of the Pfizer/BioNTech vaccine lowered rates of COVID-19 among the elderly but the protection against infection appeared short-lived, a large study in Israel found.

The U.S. health regulator said on April 5 GlaxoSmithKline and Vir Biotechnology’s antibody therapy was no longer authorized as a COVID-19 treatment, with data suggesting it was unlikely to be effective against the dominant Omicron sub-variant in the country.

The U.S. national public health agency said on April 4 the BA.2 sub-variant of Omicron was estimated to account for nearly three of every four coronavirus variants in the country.