COVID-19 vaccine makers are shifting gears and planning for a smaller, more competitive booster shot market after delivering as many doses as fast as they could over the last 18 months.

Current COVID-19 vaccines are not well-matched against the BA.2 sub-variant of Omicron, the U.S. Food and Drug Administration said on April 6, as its panel of outside experts meets to discuss changes to future booster doses.

EU health agencies recommended that Covid-19 vaccines be mixed and matched for both initial courses and booster doses as the region battles rising cases ahead of Christmas.

The Centers for Disease Control and Prevention gave the go-ahead for the use of Moderna’s and Janssen’s Covid-19 vaccines as booster shots six months and two months, respectively, after their initial series as well as the approval of mixing and matching vaccines. 

Americans can choose a Covid-19 booster shot that is different from their original inoculation but the recommendation is to stick with the vaccine they got first if available, White House chief medical adviser Dr. Anthony Fauci said on Oct. 22.