AstraZeneca Plc has begun enrolling adults for a U.S.-funded, 30,000-subject late-stage study of the company’s high-profile Covid-19 vaccine candidate.

U.S. cases of the novel coronavirus surpassed six million as many states in the Midwest reported increasing infections, according to a Reuters tally.

Global coronavirus cases surged past 25 million, according to a Reuters tally, as India marked a worldwide record for daily new cases in the Covid-19 pandemic.

The global death toll from the coronavirus surpassed 800,000 according to a Reuters tally, with the United States, Brazil and India leading the rise in fatalities.

Johnson & Johnson aims to test the company’s experimental coronavirus vaccine in up to 60,000 volunteers in a late-stage trial scheduled to start in September, according to a U.S. government database of clinical trials.

Global coronavirus cases pushed past 20 million, according to a Reuters tally, with the United States, Brazil and India accounting for more than half of all known infections.

The University of Oxford suggested that the end of 2020 is possible for the availability of a Covid-19 vaccine candidate being developed with AstraZeneca, but expressed caution about the timeline.

The World Health Organization reported a record increase in global coronavirus cases for the second day in a row, with the total rising by 259,848 in 24 hours.

Global coronavirus infections passed 14 million, according to a Reuters tally, marking the first time there has been a surge of 1 million cases in under 100 hours.

India became the third country in the world to record more than one million cases of the new coronavirus, behind only the United States and Brazil, as infections spread further into the countryside and smaller towns.