The U.S. coronavirus death toll topped 400,000 on Jan. 19, according to a Reuters tally, as the country hardest hit by the pandemic struggled to meet the demand for vaccines to stem the spread of infection.

The number of coronavirus deaths in the United States crossed 300,000 on Dec. 14, according to a Reuters tally, as the hardest hit nation rolled out its first vaccine inoculations on the same day.

California compelled much of the state to close shop and stay at home on Dec. 7, when some of the harshest coronavirus restrictions in the United States came into effect one day after the state set a record with more than 30,000 new Covid-19 cases.

Purdue Pharma LP pleaded guilty to criminal charges over the handling of the company’s addictive prescription painkiller OxyContin, capping a deal with federal prosecutors to resolve an investigation into the drugmaker’s role in the U.S. opioid crisis.

Several U.S. governors, from the coastal states of New Jersey and California to the heartland of Iowa and Ohio, acted to restrict gatherings and boost face-coverings in confronting a coronavirus surge they warned is out of control.

The city of Philadelphia will ban indoor gatherings altogether and the nearby state of New Jersey will strictly limit their size as U.S. officials struggle to slow a Covid-19 surge that could overwhelm hospitals and kill thousands.

The United States recorded more than 1 million new Covid-19 cases in the past week as new infections rose in every state except for Hawaii, according to a Reuters analysis of state and county reports.

The number of new Covid-19 cases in the United States last week rose 24% to more than 485,000 while the number of tests performed rose 5.5%, according to a Reuters analysis of state and county reports.

New York, the former epicenter of the U.S. Covid-19 pandemic, became the fourth U.S. state to surpass half a million coronavirus cases amid a nationwide surge in infections.

New York, New Jersey and Connecticut urged their residents to not travel between the three states as the U.S. Northeast sees a rise in Covid-19 cases, while California said major theme parks including Disneyland would not be opening anytime soon.