The U.S. coronavirus death toll topped 400,000 on Jan. 19, according to a Reuters tally, as the country hardest hit by the pandemic struggled to meet the demand for vaccines to stem the spread of infection.

U.S. distribution of Moderna Inc’s Covid-19 vaccine began on Dec. 19, with more than 3,700 sites due to start receiving and administering shots as soon as Dec. 21, vastly widening the rollout started by Pfizer Inc.

The United States saw a 27 percent increase in new cases of COVID-19 in the week ended July 5 compared to the previous seven days, with 24 states reporting positivity test rates above the level that the World Health Organization flagged as concerning.

As a critical industry during the COVID-19 pandemic, biopharma companies are expected to remain in operation – but with a skeleton staff. Anticipating stay-at-home mandates, life sciences companies and labs in especially hard-hit regions had already begun preparing.

Maine could soon prohibit parents from citing religious or personal beliefs to avoid vaccinating their children, making the U.S. state one of a half dozen cracking down during the nations’ largest measles outbreak in 25 years.