Hundreds of thousands of deaths, billions of dollars in healthcare costs: Fueled by an addiction epidemic, America’s opioid crisis is graver than ever.

Lawmakers on the U.S. Senate Judiciary Committee urged the Trump administration to conduct a scientific review of a Justice Department-backed bill to classify all illicit chemical knockoffs of the potent painkiller fentanyl in the same legal category as heroin.

Reckitt Benckiser Group agreed to pay $1.4 billion to settle a U.S. investigation into the sales and marketing of Suboxone Film, a product managed by the spinout company Indivior.

JPMorgan Chase & Co. cut ties with Purdue Pharma LP over the OxyContin maker’s alleged role in the U.S. opioid crisis, forcing the company to find a new bank to manage cash and bill payments, people familiar with the matter said.

The U.S. opioid crisis is taking a toll on children of users as a study published showed they were more likely to attempt suicide.

Opioid use has reached crisis proportions not only in the United States but also in Canada and some European countries, as prescription opioid painkillers have become much more common, the OECD club of wealthy nations said.

The founder of Insys Therapeutics Inc. became the highest-ranking pharmaceutical executive to be convicted in a case tied to the U.S. opioid crisis, when he and four colleagues were found guilty of participating in a scheme to bribe doctors to prescribe an addictive painkiller.

U.S. President Donald Trump touted progress in the fight against opioid abuse and promised to hold drugmakers accountable for their part in the crisis, a day after his administration brought its first related criminal charges against a major drug distributor and company executives.

Dozens of medical professionals in Appalachia – a region hard-hit by the U.S. opioid crisis – were charged with writing hundreds of thousands of illegal prescriptions and committing health care fraud, federal prosecutors said.

As America continues to grapple with the opioid crisis, nonprofit advocacy group Public Citizen is calling for the U.S. Food and Drug Administration (FDA) to place a moratorium on the approval of any new opioid medications.