The cancer immunotherapy drug helped advanced head and neck cancer patients with a dismal prognosis live longer than other standard treatments, according to late-stage study data.

Merck & Co’s immunotherapy Keytruda led to a high response rate for patients with the blood cancer multiple myeloma when added to standard therapy in a small, early stage trial, according to data presented on Monday. The Phase I study tested Keytruda in combination with Celgene’s Revlimid and the corticosteroid dexamethasone in patients whose disease […]

Bristol-Myers Squibb Co said the U.S. Food and Drug Administration had approved the expanded use of its cancer drug, Opdivo, to treat an additional form of advanced skin cancer. Opdivo, first approved in December 2014, raked in worldwide revenue of $467 million in the nine months ended Sept. 30. The drug has been approved for […]

Phase I first-in-human study to evaluate GSK’s OX40 agonist GSK3174998 as monotherapy and in combination with Merck’s anti-PD-1 therapy, KEYTRUDA® (pembrolizumab)     LONDON & KENILWORTH, N.J.–(BUSINESS WIRE)–GSK and Merck, known as MSD outside the US and Canada, today announced the initiation of a phase I clinical trial designed to evaluate GSK’s investigational immunotherapy GSK3174998 […]

New York-based Bristol-Myers Squibb Company (BMY) announced today that it is acquiring Chapel Hill, N.C.-based Cardioxyl for up to about $2.07 billion.   Cardioxyl focuses on developing drugs for cardiovascular diseases. As part of the deal, Bristol-Myers Squib picks up the company’s lead asset, CXL-1427, a novel nitroxyl (HNO) donor (prodrug) that is currently in […]

Merck & Co’s approved Keytruda lung cancer treatment provided superior overall survival to chemotherapy in a late-stage study of patients with advanced disease whose tumors produce a protein called PD-L1 associated with increased risk of the disease. The U.S. drugmaker on Monday said patients taking the approved 2 milligram dosage of Keytruda and those taking […]

Novartis has broadened its immuno-oncology pipeline with the acquisition of Admune Therapeutics and through licensing agreements with small drug developers Xoma and Palobiofarma.   Palobiofarma, a Spanish biotech company, said separately it entered into a $15 million licensing agreement with the Swiss group. Novartis said in a statement on Wednesday these transactions add Admune’s IL-15 […]

INDIANAPOLIS – Eli Lilly and Company (LLY) and Shanghai-based Innovent Biologics, Inc. have expanded their drug development collaboration to include three anti-PD-1 based bispecific antibodies for cancer treatments over the next decade, the company announced this morning.  The announcement expands on an existing deal between the two companies originally announced in March. The original deal to develop three cancer therapies could […]

AstraZeneca has temporarily halted two clinical trials combining experimental drugs to treat lung cancer, following reports of lung disease in some patients, the company said on Friday. The trials involve giving its drug AZD9291, which is currently awaiting regulatory approval, alongside the immune system-boosting medicine durvalumab, also known as MEDI4736, to treat patients with advanced […]

The U.S. Food and Drug Administration on Friday approved Merck & Co Inc’s immunotherapy, Keytruda, for patients with the most common form of lung cancer whose tumors produce a specific biological marker. The FDA approval for Keytruda in advanced non-small cell lung cancer is for patients whose tumors express PD-L1, a protein targeted by the […]