The global tally of confirmed coronavirus cases hit 60 million on Nov. 25, with the pace of new infections accelerating and the United States reporting record numbers of hospitalizations, according to a Reuters tally.

Record hospitalizations and a surging death toll failed to keep Americans from traveling a day before the Thanksgiving holiday, raising fears that the unchecked spread under way is a prelude to further contagion at Christmastime.

U.S. health officials and politicians pleaded with Americans to stay at home over the Thanksgiving holiday and abide by constraints placed on social and economic life as record coronavirus caseloads pushed hospitals to their limits.

U.S. Surgeon General Jerome Adams pleaded with Americans to grasp “the severity of the moment” and remain vigilant against the coronavirus pandemic, as record hospitalizations pushed healthcare professionals to the brink.

The United States recorded the country’s largest weekly rise in Covid-19 deaths since August, increasing 32% from the previous week to average about 1,500 people per day, according to a Reuters analysis of state and county reports.

The United States recorded the country’s 12th million Covid-19 case, even as millions of Americans were expected to travel for the upcoming Thanksgiving holiday, ignoring warnings from health officials about furthering the spread of the infectious disease.

The number of reported global daily deaths from the coronavirus reached 10,816 on Nov. 17, according to a Reuters tally, the highest single-day death count as the virus’ global epicenter the United States entered winter.

North Dakota became the 35th U.S. state to require face coverings be worn in public, as governors across the country grapple with a surge in coronavirus infections that threatens to swamp their healthcare systems.

Coronavirus cases in the United States surged by at least 120,276, according to a Reuters tally, the second consecutive daily record rise as the outbreak spreads in every region.

Moncef Slaoui, the head of Operation Warp Speed – the government project to push along the Covid-19 vaccine development – suggested the first Emergency Use Authorization (EUA) for a vaccine will likely be around Thanksgiving.