The United States is in a new phase of the novel coronavirus outbreak with infections “extraordinarily widespread” in rural areas as well as cities, White House coronavirus experts said on Sunday.

A University of Washington model projects the U.S. death toll from COVID-19 will climb to just above 224,000 by Nov. 1, up 16,000 from a prior forecast, due to rising infections and hospitalizations in many states.

Florida reported a record increase of more than 15,000 new cases of COVID-19 in 24 hours on Sunday, as the Trump administration renewed a push for schools to reopen and anti-mask protests were planned in Michigan and Missouri.

Record-breaking coronavirus cases and deaths in several U.S. states are dimming hopes of economic recovery, with cellphone data showing shoppers are staying away from stores in areas where cases are rising the most.

The United States reported more than 59,000 new COVID-19 cases on Wednesday, the biggest increase ever reported by a country in a single day, according to a Reuters tally.

Medical device maker Danaher Corp.’s COVID-19 blood test for detecting if a person had ever been infected with the new coronavirus received emergency use clearance from the U.S. Food and Drug Administration.

The governor of Texas temporarily halted the state’s reopening as COVID-19 infections and hospitalizations surged and the country set a new record for a one-day increase in cases.

Many studies assessing the accuracy of COVID-19 antibody tests had major shortcomings, a review concluded, offering further evidence the blood tests are of little use for people seeking to know with certainty if they have been infected.

AstraZeneca’s cancer drug Calquence has shown initial signs of helping hospitalized COVID-19 patients get through the worst of the disease, as researchers scramble to repurpose existing treatments to help fight the deadly infection.

Children have milder COVID-19 symptoms than adults and the balance of evidence suggests they may also have lower susceptibility and infectivity than adults, scientists advising the British government said.