New Covid-19 cases and hospitalizations appear to be on a downward trajectory in the United States as the Biden administration remains confident that it can hit its target of 100 million vaccines in 100 days, the White House Coronavirus Task Force said.

The United States is monitoring the new strain of Covid-19 emerging in the United Kingdom, with U.S. officials unclear whether the mutated variant had made its way to America.

California shattered records for coronavirus cases on Dec. 6 as U.S. states scrambled to impose lockdowns to stem spikes in infections and the White House’s task force coordinator decried a lack of national leadership on curbing the disease.

The mayor of San Francisco ordered new lockdowns and business restrictions across the Bay Area in the face of the Covid-19 surge, as political leaders nationwide ramp up pressure on Americans to stay home until vaccines can be distributed.

U.S. infectious disease expert Anthony Fauci said he was reacting to gloating by a British television interviewer when he criticized the country’s quick approval of the first coronavirus vaccine.

Dr. Anthony Fauci, the top U.S. infectious disease expert, said he has had no contact with President-elect Joe Biden’s coronavirus transition team and sees no reason to quit to join that effort when there is so much to do now to fight the surging pandemic.

The number of coronavirus patients in U.S. hospitals breached 50,000, the highest level in nearly three months, as a surge in infections threatens to push the nation’s health care system to the edge of capacity.

The White House coronavirus task force warned that much of the country is in the grips of an “unrelenting” surge in Covid-19 cases and urged tough countermeasures, as the reported number of U.S. infections hit a new daily record of more than 91,000.