Eleven Biotherapeutics Inc said its lead eye drug failed in a late-stage trial in treating patients with severe allergic conjunctivitis, sending its shares down 36 percent in after-market trading. The drug, codenamed EBI-005, failed to show statistically significant difference in treating ocular itching, compared with the vehicle arm, the company said on Friday. Eleven Bio […]

One person has been left brain dead and five others are in a serious condition after taking part in a clinical trial in France of an experimental medicine from an unnamed drug company, the French Health Ministry said on Friday. The ministry did not say what the medicine was intended to be used for. A […]

Swiss drugmaker Roche Holding released on Friday what it called encouraging results from a study of its closely watched cancer immunotherapy atezolizumab.   Roche, the world’s biggest maker of cancer drugs, said a mid-stage trial of atezolizumab in people with locally advanced or metastatic urothelial carcinoma (mUC), showed median overall survival of 11.4 months in […]

Dynavax Technologies Corp said its experimental hepatitis B vaccine was found to be safe and effective in a late-stage study, sending its shares up 9.4 percent in premarket trading. The vaccine, HEPLISAV-B, was more effective than a currently marketed vaccine, Engerix-B, the drug developer said on Thursday. The response rate in type 2 diabetes patients […]

Dutch biotech UniQure NV said on Thursday its experimental gene therapy for a blood disorder benefited some patients in an early-stage study, sending its shares up about 20 percent in light premarket trading. The drug, AMT-060, is being developed to treat hemophilia B, a condition caused by the deficiency of the factor IX gene, which […]

January 7, 2016By Mark Terry, BioSpace.com Breaking News Staff   Cambridge, Mass.-based C4 Therapeutics has exploded out of the gate with a $73 million Series A financing round and a strategic collaboration deal with Roche. C4 Therapeutics announced its launch from the Dana-Farber Cancer Institute today. The company is focused on targeted protein degradation using […]

ChemoCentryx Inc said its lead drug was found as effective as standard-of-care high-dose steroids to treat a rare autoimmune disease that causes inflammation of the blood vessels. The company’s shares rose about 18 percent in light premarket trading after it reported results from the mid-stage study. ChemoCentryx said it is developing CCX168 to assess whether […]

Recro Pharma Inc said its lead painkiller reduced pain in post-operative orthopedic surgery patients and was safe and well tolerated, in a mid-stage trial. The injectable drug, Meloxicam, had no serious adverse events, bleeding or reactions, the drugmaker said on Wednesday. Recro said patients who were given 30 mg and 60 mg doses of the […]

Conatus Pharmaceuticals Inc said its experimental drug reduced the presence of a protein fragment in patients with liver cirrhosis in a mid-stage trial. The company’s shares rose 13 percent to $3.25 in after-market trading on Tuesday. The drug, emricasan, showed a statistically significant reduction in the protein fragment, caspase-cleaved cytokeratin 18 (cCK18), when compared with […]

Eli Lilly and Co’s new Jardiance diabetes treatment has begun stealing market share from rival drugs in its class, the company said on Tuesday, bolstered by clinical trial data showing it slashed deaths by 32 percent in patients with Type 2 diabetes. In a three-year study whose results were released last summer, Jardiance became the […]