Ad Header

PharmaLive

Slogan

The Pulse of the Pharmaceutical Industry

Lilly’s Trulicity reduces heart risks in clinical study

Written by: | no-reply@reuters.com | Dated: Monday, November 5th, 2018

 

Lilly says diabetes drug Trulicity reduces heart risks in trial

 

(Reuters) – Eli Lilly and Co said on Monday that its top-selling diabetes drug Trulicity significantly reduced the risk of heart attack, stroke and heart-related death in a broad range of people with type 2 diabetes, according to results of a large clinical trial.

The company said Trulicity is the first type 2 diabetes medicine to show this sort of statistically significant heart risk reduction in a clinical trial in which a majority of patients did not already have heart disease.

“The population that we’ve studied, with and without cardiovascular disease, certainly makes these results interesting and applicable to a broad population,” Brad Woodward, senior medical director of Lilly Diabetes, said in a phone interview.

The company did not provide any details on the magnitude of risk reduction seen in the so-called outcomes trial. It said it will disclose the full results at the American Diabetes Association meeting in June, and plans to submit the data to regulators for review next year.

Once regulators agree to allow the data to be added Trulicity’s label, Lilly can begin to promote its heart safety benefits.

Trulicity belongs to a class of drugs called GLP-1 analogues that stimulate insulin production.

Other drugs in the class, including Novo Nordisk’s Victoza and GlaxoSmithKline’s Tanzeum, have also shown they reduce cardiovascular risks in diabetes patients. But those trials had a significantly higher percentage of high-risk patients with established heart disease.

Only 31 percent of those in the 9,901-patient study had heart disease, the company said.

The trial compared 1.5 milligrams of Trulicity once a week to placebo, with the primary goal a reduction in a composite of major adverse events that included non-fatal heart attack, non-fatal stroke and heart-related death.

Trulicity is expected to generate more than $3.1 billion in sales for Lilly this year, according to analyst estimates.

Lilly said the safety profile of Trulicity observed in the study was generally consistent with drugs in the class.

 

Reporting by Michael Erman in New York; Editing by Bill Berkrot

 

Reuters source:

https://www.reuters.com/article/us-lilly-trulicity/lilly-says-diabetes-drug-trulicity-reduces-heart-risks-in-trial-idUSKCN1NA1FZ

Ad Right Top

MedAdNews

Extensive pharmaceutical business and marketing intelligence. For back issues, please contact MDAD@kmpsgroup.com.

October 2018 Focus: Top 50 Pharma, Company of the Year and more!

Subscribe

Ad Right Bottom