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1

Mixing Pfizer, AstraZeneca COVID-19 shots with Moderna gives better immune response – UK study

A major British study into mixing Covid-19 vaccines found that people had a better immune response when they received a first dose of AstraZeneca or Pfizer-BioNTech shots followed by Moderna nine weeks later, according to the results on December 6.

2

Omicron may raise re-infection risk; booster protection documented

Survivors of previous infection with the virus that causes SARS-CoV-2 may be at higher risk for re-infection with the Omicron variant than with earlier versions of the virus, preliminary findings show. Additionally, a booster shot of the Pfizer/BioNTech Covid-19 vaccine appears to provide strong protection – at least in the short term – according to data from Israel.

7

Merck Pauses Enrollment for Two Phase 3 Clinical Trials of Investigational, Once-Monthly, Oral Islatravir for Pre-Exposure Prophylaxis of HIV-1 infection

Merck announced a pause in enrollment for the IMPOWER 22 (MK-8591-022) and IMPOWER 24 (MK-8591-024) Phase 3 clinical studies evaluating investigational, once-monthly, oral islatravir (ISL) – a nucleoside reverse transcriptase translocation inhibitor – for pre-exposure prophylaxis (PrEP) in people at high risk of HIV-1 infection.