Opiant Pharmaceuticals Expands Partnership with Sanofi, Signs Agreement for Manufacturing OPNT004 for Treatment of Acute Cannabinoid Overdose
SANTA MONICA, Calif., July 23, 2019 (GLOBE NEWSWIRE) — Opiant Pharmaceuticals, Inc. (NASDAQ:OPNT), a specialty pharmaceutical company developing medicines for addictions and drug overdose, today announced that it has signed an agreement with Sanofi (NYSE:SNY) to manufacture Opiant’s investigational agent OPNTOO4 (drinabant) for the treatment of Acute Cannabinoid Overdose (ACO). Opiant intends to reformulate drinabant, a high affinity, selective cannabinoid receptor antagonist, for parenteral administration in an emergency department setting. Opiant licensed exclusive global rights from Sanofi for the development and commercialization of drinabant for the emergency treatment of ACO. The manufacturing will be performed in Sanofi Újpest site (Hungary) acting as a Contract Development and Manufacturing Organization (CDMO).
“This agreement marks an important milestone in our partnership with Sanofi and the OPNT004 development program and supply chain,” said Roger Crystal, M.D., Chief Executive Officer of Opiant. “This further enhances our position as a leader in developing medicines for the treatment of addiction and drug overdose.”
ACO is most often linked to the ingestion of both “edibles”, products containing large quantities of D9-tetrahydrocannabinol (THC) that are often sold as brownies, cookies, and candies, and synthetic cannabinoids (sold with names such as “K2” and “Spice”) that are more potent, easily obtained, and less expensive than cannabis containing products. It is estimated that ACO resulted in more than one million emergency department visits in the United States in 2016, and is expected to rise with increasing legalization of cannabis in North America. Features of ACO can include psychosis, hallucinations, nausea and vomiting, as well as feelings of paranoia, agitation, panic and anxiety. These symptoms often require emergency medical attention and can take from hours to days to fully resolve. There are currently no approved treatments for ACO.
About Opiant Pharmaceuticals, Inc.
Opiant Pharmaceuticals, Inc. is a specialty pharmaceutical company developing medicines for addictions and drug overdose. The National Institute on Drug Abuse, a division of the National Institutes of Health, describes addictive disorders as chronic relapsing brain diseases that burden society at both the individual and community levels. Opiant’s first drug overdose product, NARCAN® Nasal Spray, is licensed to Adapt Pharmaceuticals, now owned by Emergent BioSolutions, Inc. For more information, visit www.opiant.com.
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