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Under the deals, first announced in July, Israel-based Teva will pay up to $4.25 billion, including a supply of the overdose drug naloxone. AbbVie will pay up to $2.37 billion. The final amounts of the settlements will depend on how many state and local governments opt into them.

Opioid overdose reversal drug naloxone may be safe and effective for over-the-counter use in some forms, the U.S. Food and Drug Administration said on Tuesday, potentially paving the way for its use federally.

The committee will reveal in a Wednesday report that after adapting a method used by CDC scientists and adjusting for inflation, it found that the crisis cost the U.S. economy $1.47 trillion in 2020, a $487 billion increase from 2019.

CVS Health Corp. and Walmart Inc. have agreed to pay $147.5 million to settle West Virginia’s claims over their alleged roles in the state’s opioid crisis, state attorney general Patrick Morrisey said Tuesday.

Johnson & Johnson has agreed to pay $40.5 million to settle New Hampshire’s claims over the company’s role in the opioid epidemic, averting a trial that had been scheduled to begin next week.

The long-awaited review of problematic prescribing of opioids is taking longer than observers had hoped. Studies of this extended use of the pain medications have lagged for years beyond their expected completion, said FDA Commissioner Robert Califf to the Associated Press.

Endo International Plc filed for bankruptcy on Tuesday after reaching a $6 billion deal with some of its creditors, as the U.S. drugmaker seeks to settle thousands of lawsuits over its alleged role in the country’s opioid epidemic.

Walgreens Boots Alliance contributed to the opioid epidemic in San Francisco through its sale of prescription drugs in the city, a federal judge concluded on Wednesday.

West Virginia’s cities and counties reached a $400 million settlement on Monday with drug distributors McKesson Corp., AmerisourceBergen Corp., and Cardinal Health Inc., resolving the local governments’ allegations that the three companies fueled an opioid crisis in the state.

AbbVie Inc.’s unit Allergan has reached an agreement to pay over $2 billion to resolve thousands of lawsuits related to the marketing of its opioid painkiller, Bloomberg News reported on Wednesday, citing people familiar with the matter.