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CVS Health Corp. on Wednesday forecast a 2023 profit below Wall Street estimates, and also announced it agreed to pay about $5 billion over 10 years to resolve thousands of lawsuits accusing its pharmacy chain of mishandling opioid painkillers.

Leading consulting firm McKinsey & Co. has agreed to settle claims by hundreds of U.S. local governments and school districts around the country that it fueled an epidemic of opioid addiction through its work for bankrupt OxyContin maker Purdue Pharma LP and other drug companies.

Walmart Inc. (WMT.N) has agreed to pay $215 million to resolve claims its pharmacies fueled an epidemic of opioid addiction in Florida, the state’s attorney general announced on Thursday.

CVS Health Corp. and Walmart Inc. have agreed to pay $147.5 million to settle West Virginia’s claims over their alleged roles in the state’s opioid crisis, state attorney general Patrick Morrisey said Tuesday.

Teva Pharmaceutical Industries expects to finalize an opioid settlement in the United States by year-end and start paying in 2023, its chief executive said on Sunday, while confirming he was unlikely to renew his contract next year.

U.S. pharmacy operators Walgreens Boots Alliance, Walmart Inc. and Kroger Co. on Tuesday faced off against the state of New Mexico in the latest trial over their alleged role in the U.S. opioid epidemic, following recent high-profile losses for pharmacies in other lawsuits.

Johnson & Johnson has agreed to pay $40.5 million to settle New Hampshire’s claims over the company’s role in the opioid epidemic, averting a trial that had been scheduled to begin next week.