Webinar: Escape from HPLC. Excipient Compatibility by Differential Scanning Calorimetry (DSC)/ Modulated DSC (MDSC)

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Webinar: Escape from HPLC. Excipient Compatibility by Differential Scanning Calorimetry (DSC)/ Modulated DSC (MDSC).

Monday, February 28, 2022 | 10 am ET / 7am PT

The pharmaceutical industry traditionally tests excipient compatibility by incubating binary mixtures of API and excipient at stress conditions and testing over time by HPLC. These tests are time consuming and take up to 3 months to complete, slowing the progress of formulation development. Furthermore, testing is performed at early stages when HPLC methods are not validated which can lead to incorrect conclusions that may only become known when the final formulated product is placed upon stability with validated methods. This is especially troublesome when using a non-validated HPLC method that may not retain an unknown evolved related compound.  Most concerning is HPLC can only detect chemical changes. DSC/MDSC analysis is a better technique over HPLC as it is faster, can detect chemical and physical changes, and is more ecofriendly using less materials (solvents, drug substance, excipients). DSC/MDSC excels in early development as no validated methods are needed. Register now.

Featured Speaker

Brent Hilker
Preformulation Manager
CoreRx

Brent has a PhD in Polymer Chemistry from the University of South Florida and has worked for CoreRX 8 years and in the semiconductor industry 4 years. Additionally, he is a 6-year veteran of the USMC.

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