WHO warns of growing resistance in individuals to GSK, ViiV’s HIV drug Tivicay

World Health Organization

WHO warns of growing resistance in individuals to GSK, ViiV’s HIV drug Tivicay

Published: Mar 06, 2024

By Tristan Manalac

BioSpace

The World Health Organization on Tuesday flagged growing HIV drug resistance against GSK and ViiV Healthcare’s antiretroviral medication Tivicay (dolutegravir), noting that observational and survey data suggest that resistance may now be higher than levels observed in clinical trials.

Results from four surveys placed resistance rates from 3.9% to 8.6%, according to the World Health Organization (WHO). In some cases, resistance reached as high as 19.6%, particularly in treatment-experienced patients who transitioned to Tivicay antiretroviral therapy (ART) while still having high viral loads. The global health authority has yet to receive survey data from all participating countries.

A report from Haiti also pointed to worrying trends of potential resistance in ART-naïve infants. One infant, whose mother had been treated with Tivicay, also showed resistance to the drug.

Meg Doherty, director of the WHO’s Department of the Global HIV, Hepatitis and STI Programs, in a statement said that the mounting global HIV resistance to Tivicay “underscores the necessity for increased vigilance and intensified efforts to optimize the quality of HIV care delivery.”

Effective viral suppression in pregnant and breastfeeding women, along with strict surveillance of resistance in newborns, is similarly crucial to stem transmission and better direct ART treatment regimens in the future, according to the WHO announcement.

These HIV resistance data come from the WHO’s latest HIV Drug Resistance Report, which aims to spot where treatment resistance is emerging globally and provide guidance to help countries monitor and respond to related challenges.

“The resistance analysis focuses on subgroups whose virus was not suppressed and the data does not indicate that resistance was prevalent in the overall population”, a GSK spokesperson told Reuters on Tuesday, adding that company agrees with the WHO “that there is a need for further surveillance.”

In a report published last week, the WHO said that most countries fell short of global standards in terms of various HIV quality of care indicators, such as ART retention, viral load testing coverage, timely switch to second-line ART and timely second viral load testing. To more effectively slow or prevent drug resistance to Tivicay, countries should conduct routine monitoring of these indicators and improve their data reporting systems, according to the global health authority.

The WHO also recommends the implementation and scale-up of pre-exposure prophylaxis (PrEP) treatments, accompanied by strict surveillance of resistance among people who test positive for HIV despite being on PrEP.

Tivicay’s active ingredient is dolutegravir, an integrase inhibitor that works by targeting the HIV’s integrase protein and blocks its active site. This mechanism of action allows Tivicay to prevent the virus from integrating its DNA into the host cell, disrupting its replication cycle.

Given its efficacy, favorable side effect profile and ease of administration, the WHO in 2018 recommended dolutegravir as the preferred first- and second-line treatment for HIV-1 across all population groups. The broad use of dolutegravir, combined with the increasing uptake of PrEP, “promises to revolutionize HIV care and prevention,” the WHO wrote in its report brief.

Source: BioSpace