Temps are falling and so is investor cash as BioSpace reviewed which biotech companies are scooping up the dollars.
When AstraZeneca presented positive updated results from the Phase III ASCEND study of CALQUENCE (acalabrutinib), it marked an important milestone for the company as the jewel in the crown of what management hopes will become a significant hematology portfolio. That study was significant for patients, too, because it represented a landmark 36 months of follow-up in chronic lymphocytic leukemia (CLL), which is considered an incurable disease.
Evolution of US Payer Management of Oncology, an examination of Non-small Cell Lung Cancer (NSCLC) and Chronic Lymphocytic Leukemia (CLL)
Analysis, Bruton's Tyrosine Kinase (BTK) Inhibitors, Chronic Lymphocytic Leukemia (CLL), Clinical Trials, Insurance Companies, Non-Small Cell Lung Cancer (NSCLC), Oncology, Payers, PD-1/PD-L1 inhibitors, R&D, Surveys, Therapeutics, United StatesTraditional management tools have proven to be ineffective at managing costs for oncology drugs, leading to a hands-off management approach in the United States. But a recent survey from Two Labs – including 25 Pharmacy Directors and Medical Directors at US insurance companies representing 112.5 million covered lives – shows that the situation might be changing. The survey aimed to gather insight about what the industry looks like with increased levels of care management by covering traditional management tools, oncology-specific tools, systemic management tools and shifting risk, value frameworks, and pathways of care.
Calquence met primary efficacy endpoint in head-to-head trial against ibrutinib in CLL
Atrial Fibrillation, Bruton's Tyrosine Kinase (BTK) Inhibitors, Chronic Lymphocytic Leukemia (CLL), Clinical Trial Endpoints, Clinical Trials, Head-to-Head Studies, Primary Endpoints, R&D, Secondary Endpoints, TherapeuticsPositive high-level results from the ELEVATE-RR Phase III trial showed AstraZeneca’s Calquence (acalabrutinib) met the primary endpoint demonstrating non-inferior progression-free survival for adults with previously treated, high-risk chronic lymphocytic leukemia (CLL) compared to ibrutinib.
ASH 2020: CRISPR and Vertex’s Potential Cure for Sickle Cell Disease and More Glimmers of Hope
Acute Myeloid Leukemia (AML), American Society of Hematology (ASH) Annual Meeting, Analysts, Bristol Myers Squibb, Business, CAR-T Therapy, CD47 Inhibitors, Chronic Lymphocytic Leukemia (CLL), Clinical Studies, Clinical Trials, CRISPR, Data, Gene Therapy, Janssen, Johnson & Johnson, Large B-Cell Lymphoma, Monoclonal Antibodies, New England Journal of Medicine, R&D, Sickle Cell Disease, Therapeutics, Transfusion-Dependent Beta-Thalassemia (TDT)The American Society of Hematology (ASH) Annual Meeting & Exposition began December 5 with numerous presentations, abstracts and posters.
New Data Reinforce Long-Term Benefit of Venclexta-Based Combination for Relapsed or Refractory CLL
American Society of Hematology (ASH) Annual Meeting, Blockbusters, Chronic Lymphocytic Leukemia (CLL), Clinical Trials, Data, Minimal Residual Disease (MRD), Progression-Free Survival (PFS), R&D, TherapeuticsRoche Group member Genentech announced that new data from the pivotal Phase III MURANO and CLL14 studies support the efficacy of fixed-duration, chemotherapy-free Venclexta (venetoclax)-based combinations in certain people with chronic lymphocytic leukemia (CLL) and provide more evidence on the potential value of minimal residual disease.
Verastem signed a definitive deal to sell the company’s global commercial and development rights for Copiktra (duvelisib) to Secura Bio.
The U.S. Food and Drug Administration approved Imbruvica (ibrutinib) in combination with Rituxan (rituximab) for chronic lymphocytic leukemia or small lymphocytic lymphoma patients who are new to therapy.
ASH Roundup: Bristol-Myers Squibb, bluebird bio, Oryzon and More
Acute Myeloid Leukemia (AML), American Society of Hematology (ASH) Annual Meeting, Chronic Lymphocytic Leukemia (CLL), Clinical Data, Clinical Trials, Diffuse Large B-Cell Lymphoma (DLBCL), Epigenetic, LSD1, Myelodysplastic Syndromes, Progression-Free Survival (PFS), R&D, Relapse/Refractory Multiple Myeloma, Small Lymphocytic Lymphoma (SLL), Small MoleculesHundreds of studies and results were presented at the 61st American Society of Hematology (ASH) Annual Meeting.
Bristol-Myers and Celgene's Liso-Cel Hits Mark in Multiple Cancer Studies
American Society of Hematology (ASH) Annual Meeting, B-Cell Non-Hodgkin Lymphoma, Cancer, CAR-T Therapy, Chronic Lymphocytic Leukemia (CLL), Clinical Trials, Hematopoietic Stem Cell Transplantation (HSCT), Immune Cells, R&D, Small Lymphocytic Lymphoma (SLL)Bristol-Myers Squibb announced positive results for the CAR-T therapy lisocabtagene maraleucel (liso-cel) in three studies at the American Society of Hematology Annual Meeting.