Rice University researchers in Houston used the foundation of CRISPR/Cas9 technology to develop “drive-and-process” arrays, or DAP for short. The name may be simple, but the technology is complex and could be as groundbreaking as its predecessor. DAP is a mechanism that enables the editing of multiple DNA sites – rather than one at a time – to comprehensively reverse polygenic diseases resulting from multiple genetic predispositions.
Researchers at Yale University published research in Molecular Biology and Evolution describing a new molecular analysis approach to quantify DNA changes that contribute to cancer growth.
AACR: Monday’s Stars Include Affimed, Hoth and Blueprint
American Association for Cancer Research (AACR), Antibodies, Checkpoint Inhibitors, Clinical Trials, DNA, Efficacy Data, Epidermal Growth Factor Receptor-Mutated (EGFRm) Non-Small Cell Lung Cancer (NSCLC), Hodgkin Lymphoma, Microsatellite instability-high (MSI-H) cancer, Non-Hodgkin Lymphoma, PD-1/PD-L1 inhibitors, R&D, Solid Tumors, TherapeuticsThe American Association for Cancer Research (AACR) Annual Meeting is running from April 7-13 in New Orleans, with hundreds of presentations on cutting-edge cancer research. The presentations run the gamut from preclinical studies to late-stage clinical trials. BioSpace looks at some of the preclinical and early-stage studies presented.
Ansa Biotechnologies, a California-based start-up focused on updating DNA synthesis technologies, is advancing toward the launch of a customizable DNA synthesis service, stemming from the development of a novel synthesis method.
Research Roundup: Nanotherapy and Islet Transplants for Diabetes and More
Business, Clinical Trials, Coronavirus Disease 2019 (COVID-19), Diabetes, DNA, Drug Delivery, Immunosuppressants, Islet cells, Messenger RNA (mRNA) Vaccines, Nature Nanotechnology, Northwestern University, R&D, San Diego (UCSD), San Francisco (UCSF), Transplants, Type 1 Diabetes, Viral InfectionsResearchers have been working to develop approaches to curing Type 1 diabetes by transplanting healthy islet cells into the pancreas. Investigators at Northwestern University have developed a technique to make the immunomodulation effect of immunosuppressive drugs more effective.
Researchers in Singapore developed the world’s largest and highest-resolution atlas of gastric cancer.
Research Roundup: Regrowing Nerve Cells in Spinal Cord Injuries and More
Breast Cancer, Cancer Cell, Cells, Central Nervous System, COVID-19 Vaccines, DNA, Glaucoma, Integrin inhibitors, Mammalian, Nanoparticles, Nerve Cells, Neurons, Northwestern University, Pregnancies, Spinal Cord, UC Berkeley, Washington University School of Medicine in St. LouisInvestigators at Washington University School of Medicine in St. Louis identified a compound that can help sensory neurons in the central nervous system to heal.
The mission of new startup Colossal, which has raised $15 million to date, is to genetically reengineer a cold-resistant elephant with all the core biological traits of the extinct woolly mammoth.
Months after landing a massive SPAC deal that carried Ginkgo Bioworks to the Nasdaq, the company is touting a manufacturing breakthrough from partner Aldevron for mRNA vaccine components.
Shape Therapeutics generated $112 million from a recent Series B financing round the Seattle biotechnology firm co-led with Decheng Capital and Breton Capital.