The mayor of San Francisco ordered new lockdowns and business restrictions across the Bay Area in the face of the Covid-19 surge, as political leaders nationwide ramp up pressure on Americans to stay home until vaccines can be distributed.

U.S. health officials and politicians pleaded with Americans to stay at home over the Thanksgiving holiday and abide by constraints placed on social and economic life as record coronavirus caseloads pushed hospitals to their limits.

The U.S. death toll from Covid-19 surpassed a grim new milestone of 250,000 lives lost as New York City’s public school system – the nation’s largest – called a halt to in-classroom instruction, citing a jump in coronavirus infection rates.

The White House coronavirus task force warned that much of the country is in the grips of an “unrelenting” surge in Covid-19 cases and urged tough countermeasures, as the reported number of U.S. infections hit a new daily record of more than 91,000.